pentobarbital will decrease the extent or result of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will minimize the extent or impact of aprepitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Contraindicated (1)pentobarbital decreases levels of vandetanib by in